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Iron Metabolism

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WHAT IS IRON METABOLISM? Di d you know that the usual iron intake is 10-20 mg per day for a person but the absorption is only 1-2 mg per day? Yes, it is that little! Iron can be obtained from the food we eat, such as meat and vegetables. Iron is an important element and is needed for the production of erythrocytes (erythropoiesis), as well as other important processes. It requires a tightly regulated process and takes place in the duodenum. In this article, we will go deeper about the process involved in iron metabolism which include iron absorption, transportation, and storage. From the diagram above, you can see the enterocyte. The left side is apical membrane and the other side is basolateral membrane. Let me tell you the process one by one so it will be easier to understand. When the iron intake is from the animal source like the meat we eat, which contains both haemoglobin and myoglobin, both of them contain heme. Inside the heme, there is iron. This iron which is in heme form is ...
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Haemoglobin Synthesis and Function & Haemoglobin Catabolism and Excretion

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What are hemoglobins ? The hemoglobins are red globular proteins, which have a molecular weight of about 68,000 and comprise almost one third of the weight of a red cell. The haemoglobin is composed of haem and globin. The main function of red cells is to carry oxygen  to the tissues and to return carbon dioxide from tissues to the lungs. The red cells contain the specialised protein haemoglobin. Hemoglobin is a specialised protein. Each red cell contains approximately 640 million of Hb molecules.             WHAT HAPPENS DURING HAEMOGLOBIN SYNTHESIS ? Haemoglobin is synthesised in the erythroblasts. Haemoglobin synthesis is divided into two synth esis which is Haem Synthesis and Globin synthesis. Haem synthesis occurs  in the mitochondria and the globin synthesis occurs in the polyribosomes. Hemoglobin develops in cells in the bone marrow that become red blood cells. Each molecule of an adult haemoglobin (Hb-A) consists...
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Erythropoiesis and Factors Affecting Erythropoiesis

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Erythropoiesis is the scientific term for the production of the red blood cells (erythrocytes) from the bone marrow called stem cells. Erythrocytes are vital for your health. They carry almost all the oxygen in your body which is used to make almost half of your blood. 8 out of 10 cells in your body are red blood cells. The marrow of certain bones constantly produces red blood cells. As noted previously, the marrow spaces of the vertebrae, ribs, breastbone, and pelvis are the primary sites of red cell generation, or erythropoiesis, in adults. The erythroblast, a nucleated cell that lacks hemoglobin, is the fundamental precursor from which the red blood cell is produced in the bone marrow. Bone marrow is the tissue in your bones that functions as the factory for producing blood cells. For starters, the bone marrow creates stem cells and then these stem cells will then develop into more specialized cells called Common myeloid progenitors (CMP) and has the ability to mature into all of th...
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Hemopoiesis

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WHAT IS HEMOPOIESIS? Before we go further into hemopoiesis, let’s get to know general information about the components of blood in our body. There are more than 10 different types of cells in our body, which are categorized under 3 main categories, Red Blood Cells (also known as Erythrocytes). The second is White Blood Cell (also known as Leukocytes), and the last is Platelets (also known as Thrombocytes). Thinglink. (n.d.). Composition of Blood. Www.thinglink.com. Retrieved October 2, 2022 ‌ Red blood cells contain the oxygen-carrying protein that is called hemoglobin. In the healthy adult male, they have about 5.4 million red blood cells per microliter of blood, while for a healthy adult female it is about 4.8 million. Red blood cells also are responsible for transporting oxygen because it has an internal space that is available for oxygen transport since they have no nucleus at all.  Types of White Blood Cells (Leukocytes) with Functions and Picture . (2019, November 28). Scienc...
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Component of Blood, Morphology and Functions of Each Blood Cells

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What does blood do? First of all, you need to know first what is basically a thing called blood. Blood is an essential fluid created in our body. It has a bit of a sticky texture and definitely thicker than the water, which contributes to 8% of the total body mass. Blood normally has a temperature of 38°C where it is usually one degree higher than normal body temperature and slightly alkaline where the average pH is 7.4. The volume of blood normally depends on each of our body size and weight but for a normal adult, the average volume of blood consisting in their body is 5 liters. The color of blood depends on its oxygen content. Blood that is full of oxygen is bright red in color but unsaturated with oxygen, it is dark red. Blood Component Going into deeper details about blood, you must know blood also has its components. The whole blood has two components where there are 55% blood plasma, a watery liquid extracellular matrix that contains dissolved substances, and 45% formed element...
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